Allergic reactions (PEG) to the COVID-19 vaccine

Allergic reactions (PEG) to the COVID-19 vaccine

From the first data of the anti COVID-19 vaccination campaign, 21 cases of allergic reactions (PEG) were found out of 1,900,000 doses administered, therefore we are talking about 11.1 cases per million doses administered; anaphylactic reactions following influenza vaccine administration were estimated at approximately 1.3 cases per million administrations. Studies currently underway confirm these values.

allergic reactions to the anti covid vaccine and to peg

There has been a lot of talk about anaphylactic reactions to the COVID-19 vaccine. The responsible for these allergic reactions is generally PEG (polyetylenglycol), a chemical substance present in many drugs, which is on sale in pharmacies under the trade name of “Movicol”, “Dicopeg” and “Pediapax”, widely used drugs against constipation, even in pediatrics. The PEG is present in the anti COVID-19 vaccine both from Pfizer and from Moderna in obviously very low doses, the one you buy WITHOUT RECIPE in the pharmacy for constipation contains over 6 grams per sachet.

The guidelines regarding vaccination for COVID-19 in allergic patients provide for an accurate medical history, in case of confirmation of previous allergies the patient is invited to have an allergy consultation; if the consultation gives a positive opinion, the vaccination will proceed in a protected environment and the patient will have to wait 60 minutes after the vaccine instead of the 15 minutes foreseen for the other patients. Polysorbate 80, which generally shows a cross-allergy with PEG, is contained in the vaccine Astra Zeneca and Johnson & Johnson

allergic reactions to the vaccine against covid and for PEG

In case of suspicion of allergy to PEG and / or polysorbate 80, skin allergy tests (Prick test) can be performed at increasing doses; in case of negativity, an intradermal injection will be made for further certainty.

We must bear in mind that, as specified above, polysorbates, which are also frequently used in pharmacology, cross-react with PEG, that is, those who have had an allergic reaction to polysorbates will most likely have an allergic reaction with PEG as well.

I would like to point out that many patients without their knowledge have taken common drugs containing PEG and / or polysorbates during their life, in this regard here is a list of drugs containing PEG and / or polysorbate.

 It is obvious that those who have taken one of these drugs without having allergic reactions will be able to get the anti covid vaccine with the certainty of not undergoing allergic reactions ..

list of drugs containing PEG and polysorbate

Active Principle (Trade Name)

Metilprednisolone acetato                         (Depomedrol)

Medrossiprogesterone acetato                 (Depoprovera)  

Fosfolipidi esafluoruro di zolfo                  (SonoVue)                         

Trastuzumab                                                  (Ogivri)                               

Rilonacept                                                      (Arcalyst)                            

Liposomi Perfluropropano                          (Definity)                           

Cetirizina compresse                                    (Zirtec)                               

Paclitaxel                                                        (Taxolo)                            

Trastuzumab                                                  (Herceptin, Herzuma, Kanjinti,Ontruzant)

 Metossipolietilenglicole-epoetina beta   (Mircera)

PEG-asparaginasi (Oncaspar)

Pegfilgrastim (Neulasta)

IFN-α pegilato (PegIntron, Pegasys)

Amiodarone Cloridrato Polisorbato 80 Antiaritmico

Docetaxel (Taxotere)

Insulina Glargine (Lantus)

Insulina glulisina (Apidra)

Dulaglutide (Trulicity)

Interferon beta 1a Pegilato (Avonex, Plegridy)

Omalizumab (Xolair) Trastuzumab ( Herceptin, Herzuma, Kanjinti) Siltuximab (Sylvant)

Paliperidone (Invega) Adalimumab (Humira)

Guselkumab (Tremfya)

Infiximab (Remsima)

Interferon alfa-2b (Intron A)

Docetaxel (Taxotere)

Elotuzumab (Empliciti)

Atezolizumab (Tecentriq)

Avelumab (Bavencio)

Bevacizumab (Avastin,Zirabev)

Daratumumab (Darzalex)

Denosumab (Prolia)

Dinutuximab (Unituxin)

Enfortumab (Padcev)

Olaratumab (Lartruvo)

Palifermin (Kepivance)

Trastuzumab (Herceptin,Tra zimera)

Belantamab (Blenrep)

Polisorbato 20

Inotuzumab ozogamicin (Besponsa)

Ipilimumab (Yervoy)

Isatuximab (Sarclisa)

Mogamulizumab (Poteligeo)

Moxetumomab pasudotox (Lumoxiti)

Nivolumab (Opdivo)

Ofatumumab (Arzerra)

Pembrolizumab (Keytruda)

Ramucirumab (Cyramza)

Rituximab (Truxima, Rituxan, Ruxience)

Etoposide (Toposar)

Medrossiprogesterone acetato (Depo-Provera)

Triamcinolone Acetonide (kenacort)

Imiglucerase (Cerezyme)

Somatropin (Nutropin AQ Nuspin 5)

Erythropoietin (Retacrit)

Pegfilgrastim (Neulasta)

Romiplostim (Nplate)

Darbepoetina alfa (Aranesp)

Filgrastim (Accofil, Nivestim, Granix, Zarzio ecc)

Peginterferon (Pegasys Pegintron)

Interferon beta-1a (Avonex)

Sarilumab (Kevzara)

Dupilumab (Dupixent)

Mepolizumab (Nucala)

Secukinumab (Cosentyx)

Inibitori dell’interleuchina

Aflibercept (Eylea)

Ranibizumab (Lucentis)

Brolucizumab (Beovu)

AVAXIM Hepatitis Vaccine

FLUAD Inactivated influenza vaccine

GARDASIL 9 Human Papillomavirus Vaccine 9-

valent

PREVENAR 13 Pneumococcal polysaccharide vaccine

conjugated

REVAXIS Diphtheria, tetanus and

poliomyelitis (inactivated).

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